Resected and spared pairs within the clinical seizure-onset zone showed similar interictal features

In 19 patients with stereo-electroencephalography (SEEG), we compared archived interictal feature values between resected and spared bipolar pairs inside the clinical seizure-onset zone (SOZ). The data comprised unchanged per-pair feature tables from OpenNeuro ds004100 (HUP; 14 patients) and ds003876 (NIH; 5 patients), based on 120-s clips, with no new signal processing. For each patient with at least two pairs in each group, we calculated the area under the receiver operating characteristic curve (AUC) for resected versus spared pairs and tested the group mean with an exact two-sided sign-flip test; Holm correction covered three primary features. Mean AUCs were 0.586 for 80–150 Hz high-frequency activity (95% CI 0.496–0.679; p=0.089; Holm p=0.27), 0.507 for line length (95% CI 0.393–0.623; Holm p=0.91), and 0.559 for spike rate (95% CI 0.430–0.686; Holm p=0.79). Seven secondary features ranged from 0.46 to 0.56 (all p>0.25). In the same patients, SOZ versus non-SOZ AUCs were 0.668–0.709 (p≤0.003). These results did not show that interictal features separated resected from spared SOZ pairs; a small HFA difference is not excluded. The study had low power (n=19), used two cohorts and clinical labels, did not establish why SOZ pairs were spared, did not assess outcomes, and analyzed short clips.

epilepsy · stereo-electroencephalography · SEEG · seizure-onset zone · interictal · resection · AUC · OpenNeuro