sciscape Publications
← All publications
q-bio.NC · Neurons and Cognition

Open-loop 50 Hz stimulation did not improve paired-associate recall in RAM PAL2

In 20 patients from OpenNeuro ds005494 v1.0.1, we compared recall of stimulated and non-stimulated items within lists during paired-associate encoding and cued retrieval. Exact two-sided sign-flip tests across patients found no improvement with 50 Hz open-loop stimulation: the encoding effect was -3.4 percentage points (95% CI -8.6 to +1.1; p = 0.22), and the retrieval effect was -1.7 points (95% CI -6.1 to +2.4; p = 0.45). The difference between phase effects was +1.7 points (95% CI -4.9 to +7.6; p = 0.61). Depth and medial temporal lobe subgroups had more negative estimates, but the groups were small and these results were not significant. Stimulation did not change response latency or error type. These behavioral results do not show a memory benefit from fixed-time 50 Hz stimulation; they do not test neural responses or establish effects for other stimulation methods.

open-loop stimulation · cued recall · paired-associate memory · intracranial stimulation · RAM PAL2 · memory prosthesis

Admitted 1 citing publication

References

3
  1. supportsOpen-loop stimulation during word encoding reduced recall by 1.6 points overall and 4.3 points at hippocampal sites sci:sha256:3a50433ef645749679239857437f277c2d17f9ae681ef4ff329341dc5afe1650

    Open-loop encoding stimulation did not improve cued recall in PAL2 either (upper 95% bound +1.1 points). The direction of the estimate was negative, as in FR2/catFR2.

  2. supports50 Hz open-loop depth stimulation during word encoding decreased later recall in ds005489; surface stimulation showed no effect sci:sha256:4636af3ff0cc862353979c5b008d8dee3803276e9ab70b7bea23c76a9bba0bf0

    In a different task (cued recall, PAL2), encoding stimulation also did not improve recall. The estimate was negative and most negative at depth sites (-7.4 points, n = 7). Alone, this estimate is not significant.

  3. usesdoi:10.18112/openneuro.ds005494.v1.0.1

    The behavioral event and electrode-table files used for this analysis are from OpenNeuro ds005494 v1.0.1.

Cited by

1 publication

Public catalog entries on Sciscape.