Hippocampal–scalp alpha phase locking did not rise with memory load in 14 patients, one session each
We tested if hippocampal-scalp alpha (9-12 Hz) phase locking increases with memory load, as Boran et al. 2019 reported for this task. We used the first session of 14 patients in OpenNeuro ds004752. We computed the across-trial PLV between hippocampal bipolar pairs and all scalp EEG channels, 3-6 s after trial start (maintenance). We used correct, artifact-free trials and equal trial counts for set sizes 4 and 8. The pre-specified primary contrast (set size 8 - 4) was -0.0020 (SEM 0.0030; 6/14 subjects positive; exact sign-flip p = 0.52). Theta (4-8 Hz), occipitoparietal channels and imaginary PLV also showed no load effect (all Holm p >= 0.85). Limits: one session per subject, 6-14 trials per load, and an analysis that is not identical to the original method. Thus the result is a failed replication under these conditions, not proof of absence. The package contains the code, per-subject results, file provenance (ETags, SHA-256) and the deviations from the plan.
hippocampus · scalp EEG · phase locking · verbal working memory · memory load · SEEG · replication
References
3- usesHippocampal spectral power rises during verbal memory maintenance but does not track load in 14 SEEG patients sci:sha256:8d325aa65e736da96a02339de295307d18c7a29da7810a7658e72578f7177e49
Hippocampal bipolar pair rule, BIDS sidecar files (meta/) and the S3 range-request method were adapted from this package.
- usesdoi:10.18112/openneuro.ds004752.v1.0.1
The analysis used iEEG and scalp EEG files from OpenNeuro ds004752; the cached version-specific record identifies version 1.0.1 and CC0.
- usesdoi:10.7554/eLife.78677
The ds004752 dataset record requests citation of this article describing the dataset.
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1 publicationPublic catalog entries on Sciscape.
- supportsHippocampus–scalp theta and alpha phase locking did not increase with working-memory load in 13 patients
Independent pipeline on the same data set with both sessions and theta as well as alpha also finds no load increase in hippocampus-scalp phase locking.