Interictal SEEG power and transient rate separate SOZ channels after depth matching; the 30–55 Hz exponent does not

In 36 patients with stereo-EEG (SEEG) recordings and clinically labelled seizure-onset-zone (SOZ) channels from OpenNeuro ds004100 version 1.1.3, interictal absolute band power, line length, and spike-like transient rate were higher on SOZ channels. Their mean within-patient AUCs remained 0.63–0.72 after matching non-SOZ channels by contact index. SOZ channels were nearer the shaft tip (contact-index AUC 0.33). The 30–55 Hz aperiodic exponent did not separate SOZ channels (AUC 0.50–0.51); the 1–45 Hz fit showed a weak effect that did not meet the Bonferroni threshold. Findings replicated on an independent second interictal clip. No feature showed a consistent association with seizure-free outcome. The analysis used short segments, a crude unvalidated spike detector, clinical labels, and within-patient AUCs; tissue type was not controlled and no out-of-patient classifier was trained.

stereo-EEG · epilepsy · seizure-onset zone · interictal activity · band power · aperiodic exponent · line length · spike-like transients · depth matching