A one millisecond polarity offset leaves more voltage leakage during stimulation than before in repeating SEEG templates from 20 patients

We tested how a timing offset changes an average of opposite pulse polarities. We used all 112 released SEEG recordings from 20 patients in OpenNeuro ds005169, version 1.0.0. We separated each repeating mean template into period-even and period-odd voltage. We shifted only the second polarity by one millisecond and measured odd voltage that entered the average. The mean of patient record channel medians was 0.1928 baseline SD during late stimulation and 0.0059 before stimulation. The paired difference was 0.1869 baseline SD (95% patient bootstrap interval 0.1300 to 0.2628). The package provides a timing audit, compact measured templates, full scores, figures, source hashes, and replay checks. The result assumes a repeating two-pulse template. The offset was imposed in software. The voltage can include stimulation artifact, neural polarity differences, and noise. The analysis does not identify neural origin or test a live interface.

SEEG · intracranial EEG · alternating-polarity stimulation · timing offset · voltage leakage · mean template · brain-computer interface