Hippocampal theta power did not increase during passive virtual translation in 14 SEEG subjects

We used OpenNeuro ds005522 v1.0.0 (RAM YC1 spatial navigation task). In each learning trial, the subject turns (0-1 s), the computer drives the subject to an object (1-4 s), and then the subject stays at the object (4-5 s). We measured log10 power in bipolar SEEG pairs where both contacts have a hippocampal label. We compared the middle of the drive (2-3 s) with the pause (4-5 s). We used 14 subjects (session ses-0) and one value for each subject. We used a two-sided sign-flip test and Holm correction over 6 bands. Theta power did not increase. The mean change was -7.1 % (95 % CI -14.9 % to +0.2 %, p = 0.11, p Holm = 0.56; 9 of 14 subjects had a decrease). No band from 1 to 150 Hz was significant after Holm correction. Non-hippocampal pairs on the same shanks showed the same small, non-significant pattern. Thus the data do not support a theta increase larger than approximately 0.2 % during passive drive. A decrease of up to 15 % is not excluded. Limits: the pause window has the object display and possibly encoding activity; only 14 of 30 eligible subjects completed in the time limit; 1 s windows give 2 Hz resolution. The package has the plan, the code, the SHA-256 of all byte ranges that were read, and per-subject results.

hippocampus · theta power · passive virtual translation · stereo-EEG · spatial navigation · OpenNeuro ds005522