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q-bio.NC · Neurons and Cognitionstat.ML · Machine Learning

Adding trial residual correlation gave no clear gain in a fixed strength prediction test of 52 mouse V1 inhibitory connections with test mice excluded

We tested whether trial residual calcium correlation adds information about measured inhibitory connection strength after mean visual response similarity, soma distance, and response signal fractions are given. Each test mouse was excluded from ridge fitting and feature scaling. In 52 PV-to-pyramidal connections from 18 mice, the added measure reduced mean squared log voltage error by 4.11%. The central 95% range from 1,999 whole-mouse bootstrap refits was -19.15% to +26.18%. A secondary test of 40 pyramidal-to-PV connections increased error by 3.43%. Neither test gave a clear added gain. These ranges do not establish equal performance. The package preserves selected processed trial arrays for 93 cells, voltage means, an alignment audit, code, results, and figures. The data are selected local connections, and calcium residuals do not identify synaptic causation.

structure and function · synaptic strength · visual cortex · parvalbumin · noise correlation · calcium imaging · prediction · open data

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References

7
  1. usesdoi:10.1016/j.neuron.2023.12.013

    We use the measured visual responses, paired connection strengths, cell matching rules, and source residual correlation method.

  2. usesdoi:10.25418/crick.23295188.v1

    This is the pinned version 1 source dataset. We preserve a selected subset of its processed visual trials and paired voltage means with source author credit.

  3. usesWith matched windows, response timing cut error by 0.8 to 1.8% in fixed ridge tests of 52 mouse V1 inhibitory connections sci:sha256:b79f7a9311ad5d1158ef90ecd66f8169a9f356b8c6569dea68f0bed4dc66c277

    We use its verified cell matches, selected connection records, mean voltage traces, and unchanged MIT extraction and retrieval code. We add selected trial arrays and a test of residual activity.

  4. Visual similarity after mean time course removal was linked to strength in 52 mouse V1 inhibitory connections; estimates within mice were uncertain sci:sha256:7b4b7a4b81de217610e022e581a83de2f2968e8d39eddef4fd49c2ee87938e55

    This prior analysis separated stimulus-specific mean responses from shared mean time courses. Our test asks about residual activity across repetitions.

  5. With each mouse excluded from ridge fitting, visual similarity reduced mean squared log voltage error by 3.64% in 92 mouse V1 connections sci:sha256:e93100599f4b4917da9d30754b9d75072b08d954278e6854092dd5a41e146899

    This prior test assessed mean response similarity with test mice excluded. We test added trial residual information after the mean response measure is given.

  6. doi:10.1038/nature14182

    This prior study linked visual response similarity and excitatory synaptic strength.

  7. doi:10.1038/nn.2876

    This prior study examined signal and noise correlations together with local excitatory and inhibitory connectivity.

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