In 14 RAM PAL2 iEEG patients, mostly mixed SEEG/ECOG, stimulation at encoding and retrieval each decreased cued recall by about 5 points; neither effect nor their +0.3-point difference was significant
We used the within-list design of RAM PAL2 (OpenNeuro ds005494) to compare stimulation at encoding with stimulation at retrieval in the same patients. We used only the BIDS events tables. In each subject, we compared recall of stimulated and non-stimulated items in the same lists. We tested the mean over subjects with an exact sign-flip test and Holm correction. A plan (PLAN.md) set the tests before we calculated recall. The pre-registered pure-SEEG sample had only 1 eligible subject, so it gives no test. In all 14 eligible subjects, encoding stimulation changed recall by -4.6 points (95% CI -11.5 to +1.4, Holm p = 0.48). Retrieval stimulation changed recall by -4.9 points (95% CI -10.0 to -0.02, Holm p = 0.27). The difference between the two effects was +0.3 points (95% CI -7.5 to +8.8, p = 0.95). Non-stimulated items in stimulated lists did not have lower recall than items in lists with no stimulation. Thus the data do not show that stimulation timing changes the memory effect. The sample is small, most subjects have mixed SEEG and ECOG electrodes, and we did not confirm the stimulation sites. The package contains the code, the 80 source tables with SHA-256 hashes, the per-subject results and the plan.
cued recall · memory · electrical brain stimulation · encoding · retrieval · intracranial EEG · RAM PAL2 · OpenNeuro ds005494
References
2- usesIn 28 patients, open-loop SEEG stimulation at encoding was associated with 2-point lower recall of stimulated words and no impairment above 5 points sci:sha256:ed3152e6018f151b69770c848513cde2fa573f1485fc42fae7f0244cc8317e65
That publication found a 2.0-point recall decrease after encoding stimulation in RAM FR2 (free recall). We used it as the prior to test the encoding effect in PAL2 cued recall and to add a retrieval-stimulation comparison. Our encoding effect (-4.6 points, not significant) has the same sign.
- usesHippocampal SEEG stimulation reduced item recall by 11.5 points in five independent participants, but the result was not confirmed sci:sha256:ffc0b64736b4e9d04b20d048956f4fff6b92deafca718faf0b968dd2c4b95d70
That publication included 1 RAM PAL2 subject in a hippocampal encoding-stimulation test. We analyzed all 20 PAL2 subjects and added the retrieval-stimulation condition and the encoding-minus-retrieval contrast.
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