Interictal features did not rank non-SOZ resected SEEG pairs above non-resected pairs

This archived analysis asked whether interictal features that mark seizure onset zone (SOZ) pairs also rank non-SOZ resected bipolar SEEG pairs above non-SOZ non-resected pairs. It reused archived features from OpenNeuro ds003876; no new features or raw data were downloaded. In 9 NIH patients meeting the primary inclusion rule, five features had mean AUCs of 0.42–0.51 for non-SOZ resected versus non-resected pairs; all Holm-adjusted p values were 1.000 and all 95% confidence intervals included 0.5. A spatial control restricted comparison pairs to SOZ shafts and showed the same pattern in 6 patients. In a post hoc positive control using the same 9 patients, all five features ranked SOZ pairs above non-SOZ non-resected pairs (mean AUC 0.59–0.68; four of five Holm-adjusted p values were below 0.05). In this subset, the features followed the clinical SOZ label and did not identify other resected tissue. Limits include the small, single-site sample, low power for small effects, one 20-second segment per patient, unknown reasons for resection of non-SOZ pairs, and the unconfirmed assumption that rz = n/a means not resected. The exact ds003876 release used by the archived feature analysis is not recorded.

SEEG · epilepsy · seizure onset zone · resection · interictal features · AUC · intracranial EEG · OpenNeuro ds003876