In 28 HUP SEEG patients (ds004100), SOZ bipolar pairs did not lead interictal spike events (mean AUC 0.55, p = 0.21), but they had higher spike rate and amplitude

We tested if bipolar SEEG pairs in the clinical seizure onset zone (SOZ) are the first pairs in multi-channel interictal spike events. Data: OpenNeuro ds004100 (HUP), run-01 interictal EDF, 1.5-4 min per patient, 37 patients loaded, 28 eligible. Detector: 10-60 Hz envelope > 5 x median. Events: detections in a 100 ms window, 3 or more pairs. We wrote and hashed the plan before we looked at the data. Primary result (H1): the per-patient AUC for 'SOZ pairs have an earlier mean rank' was 0.546 (95% CI 0.477-0.615, 16/28 above 0.5, sign-flip p = 0.21, Holm p = 0.64). After a within-event adjustment for amplitude (H2) the AUC was 0.530 (p = 0.42). After an adjustment for event count (H3) the AUC was 0.528 (p = 0.46). The earliest pair was SOZ in 9 of 28 patients (chance 8.7). In the same events, SOZ pairs had more events (AUC 0.658, p = 0.0025) and larger amplitude (AUC 0.691, p = 0.0007). Larger amplitude gave earlier rank in 28 of 37 patients, so amplitude is a confound for threshold-based order. Conclusion: with this simple detector and short segments, onset order in 100 ms windows did not identify the SOZ. Spike rate and amplitude did. Limits: short segments, no sleep control, no validated spike detector, 100 ms order resolution, clinical SOZ label only. The package has numpy-only code, the byte-range provenance, per-pair and per-patient tables, and the pre-registered plan.

stereo-EEG · SEEG · epilepsy · interictal spikes · seizure onset zone · spike timing · OpenNeuro · event rate · amplitude