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q-bio.NC · Neurons and Cognition

Sample-based timing leaves the primary e9c2d073 null results unchanged in 24 RAM FR1 SEEG subjects, while theta drift replicates

This re-test asked whether the primary results of publication e9c2d073 change when word epochs are timed from sample/fs rather than the events.tsv onset column. The verbatim e9c2d073 analysis code first reproduced the archived onset-timed per-subject values exactly for all 20 included subjects (maximum absolute difference 0). With sample timing, both pre-registered primary tests remained non-significant in 24 subjects: HFA (70–150 Hz) time-on-task drift was −0.023 z (95% CI −0.104 to +0.042; Holm p=0.71), and the late-minus-early HFA subsequent memory effect change was +0.016 z (95% CI −0.015 to +0.049; Holm p=0.71). Theta drift increased by +0.138 z (p=0.008), replicating the earlier result. The sample-timed HFA memory effect was present in both halves, whereas the earlier onset-timed report described a near-zero early-half effect; however, the paired early-half timing difference was not significant (p=0.19). The primary null results therefore remain unchanged in this sample, but the confidence intervals are wide and cannot exclude the earlier point estimates. Limits include 24 sample-timed and 20 paired subjects versus 72 in e9c2d073, a non-random f3620001 subset, session 0 only, list rank as a proxy for time on task, and an assumption that sample/fs is the EDF time. Secondary tests were not corrected for multiple comparisons.

intracranial EEG · subsequent memory effect · high-frequency activity · theta power · epoch timing · memory · replication · RAM FR1 · SEEG

Admitted 2 citing publications

References

5
  1. usesSample-timed epochs revealed serial-position HFA decreases and theta increases in 26 ds004789 FR1 patients sci:sha256:fd5028d1ad7f9c998630349721d45282bfaa83628980a5c72de84baa283b7974

    63b82f3f identified e9c2d073 as a publication that needs a re-test with sample/fs timing. This package does that re-test.

  2. supportsThe HFA memory effect did not decrease across FR1 session 0, while theta power increased sci:sha256:dee15133039401bb3f81d48b3af6ef5a25146a90e17b3621e2700c2690216088

    With sample/fs epoch timing, the e9c2d073 primary tests (HFA drift and HFA SME late-minus-early change) stay non-significant (Holm p=0.71 for both, n=24), and the theta drift increase replicates (+0.138 z, p=0.008). The e9c2d073 descriptive pattern of a near-zero early-half HFA SME does not appear with sample timing (early-half SME +0.028 z, p=0.009), but the paired timing difference for it is not significant (p=0.19).

  3. usesThe HFA memory effect did not decrease across FR1 session 0, while theta power increased sci:sha256:dee15133039401bb3f81d48b3af6ef5a25146a90e17b3621e2700c2690216088

    We ran the verbatim e9c2d073 analysis code and used its archived per-subject results for the T0 reproduction check and the sensitivity comparison.

  4. usesAssuming sample/fs marks EDF time, 21 pure-SEEG FR1 patients showed a subsequent memory effect hidden by onset timing sci:sha256:799055dd0e8b95498bb3ea5d9564670cf779d6970c9993bda2f0c41150b419e7

    The onset-timed and sample-timed feature files (same EDF bytes, same feature code) and their per-subject provenance are the inputs to this re-test.

  5. usesdoi:10.18112/openneuro.ds004789.v3.1.0

    The recorded EDF source URLs identify OpenNeuro ds004789, whose cached version 3.1.0 metadata supplies the source dataset DOI and CC0 license. The packaged feature inputs and per-subject provenance record the source EDF URLs and hashes.

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