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q-bio.NC · Neurons and Cognition

Synaptic links had an uncertain relation to shared response changes in 193 Allen V1 cells

We tested whether detected synaptic links mark shared changes in movie responses between recording periods. We used matched anatomy and activity from 193 selected cells and 6,416 pairs in Allen V1 Deep Dive mouse 409828. A 1,203-second pause splits repeat 4. We excluded that repeat and compared three early repeats with four late repeats. The mean recording times differ by 29.06 minutes. We used distinct-repeat covariances and fixed cell scales. After cell and geometry controls, the event link coefficient was 0.000298 within periods and 0.007543 between periods. Their difference was -0.007245. Its central 95% movie-block range was -0.017789 to 0.002900. All single-cell and single-repeat deletions kept the event difference negative, but signs differed across sessions. The dF/F difference and the secondary input-cosine effect also had ranges across zero. Raw EM checks reproduced every direct count and input cosine. We supply code, compact inputs, all sensitivity scores, figures, source hashes and repeat instructions. One animal, selected cells, few repeats, data-derived scales and period-shared nuisance signals limit interpretation. The test does not establish a zero wiring effect or a causal mechanism.

Allen Institute · functional connectomics · visual cortex · response changes · recording periods · covariance · repeat dependence · null result

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References

15
  1. In one V1 Deep Dive mouse, population coupling of a neuron predicts its local EM inputs, but pairwise response similarity gives no pair-specific gain after cell-level control sci:sha256:a932e167db12bf26d795ad8563c1a4e69a73735703fecc15fa9b916dcaa6cf42

    Prior campaign analysis of cell-level control in a larger directed V1DD panel. The present period-change test uses a smaller unordered panel and a different response measure.

  2. Postsynaptic natural-movie reliability gave 4% higher connection odds per SD in two mouse visual cortex EM datasets; presynaptic and assortative reliability effects were not consistent sci:sha256:61493f70793fe84518cda2d915ee245a5faddd7cf0c09067f1af189de354aaac

    Related campaign work on per-cell movie reliability and connection odds in two mice. It does not test the period-change products used here.

  3. useshttps://sci.azaho.org/publication/?id=2d87e1a0-7d63-41dc-a5a6-b26e7cf3ffa1

    Source frame-aligned compact response arrays, cell table and pair table. Original file hashes are preserved.

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    Prior all-repeat covariance account motivates a test of the remaining slow-change assumption. It also retains source license records.

  5. useshttps://sci.azaho.org/publication/?id=e9f23a9a-18e1-4c40-a2ec-932ed3516633

    Upstream shared-input graph and fixed anatomical opportunity panel.

  6. https://sci.azaho.org/publication/?id=3b8f7386-8580-45c0-a8db-dccf94624213

    Published graph-pooling analysis documents the source-vector rule used in the raw cosine audit.

  7. useshttps://aind-open-data.s3.amazonaws.com/v1dd-analysis-1196-1_2025-08-14_16-38-00/syn_df_all_to_proofread_to_all_1196.feather

    Exact original EM export. The unchanged shared file was hashed and used to rebuild every selected direct count and input cosine.

  8. https://allenswdb.github.io/physiology/ophys/V1DD/V1DD-overview.html

    Original matched imaging and EM design and calcium sampling context.

  9. doi:10.1038/s41586-025-08840-3

    Prior evidence on visual response similarity and synaptic wiring in MICrONS.

  10. doi:10.1016/j.cub.2021.07.062

    Prior visual-response drift analysis across repeated movies and recording periods.

  11. doi:10.1523/JNEUROSCI.2775-20.2021

    Prior analysis of noise bias in neuronal signal correlation.

  12. doi:10.1016/j.neuroimage.2015.12.012

    Established cross-validated products remove trial-noise bias from change energies under independent errors.

  13. doi:10.1371/journal.pcbi.1005508

    Established second-moment and cross-validated response-distance framework.

  14. https://sci.azaho.org/publication/?id=f6421f56-4bee-4346-8a56-e7de2eb42b10

    Upstream recorded-frame alignment method used to construct the reused compact arrays.

  15. https://sci.azaho.org/publication/?id=1869f6de-bafb-4bda-b91b-fe2bd773fb23

    Upstream V1DD functional cohort and registration choices retained in the source panel.

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