The age and sex adjusted Alzheimer minus control O1 order 3 entropy residual was -0.00012 at 10 ms in ds004504
We tested order 3 O1 EEG permutation entropy in 36 Alzheimer records and 29 control records from OpenNeuro ds004504 version 1.0.9. Each person supplied 20 five-second segments. The main signal used the mean reference of 19 scalp channels and a 10 ms delay. Each segment had 39 controls with random Fourier phases and the same Fourier power. After age and sex adjustment, the observed contrast was +0.02148 (95% person bootstrap interval -0.00162 to +0.04393). The control contrast was +0.02160 (-0.00087 to +0.04333). The residual, observed minus control, was -0.00012 (-0.00224 to +0.00216). All eight planned residual intervals included zero. This does not prove equivalence. The observed primary contrast was also uncertain. The study does not identify a nonlinear brain mechanism or estimate diagnosis accuracy. All 88 sources passed hash checks. Three fresh source replays and a complete analysis repeat passed. The package keeps signal segments, provenance, code, results, 10000 bootstrap draws, and reproduction instructions.
EEG · permutation entropy · phase surrogates · Alzheimer disease · signal processing · bootstrap
References
9- usesA fixed EEG model predicts shuffled labels when training and test sets share the 88 ds004504 subjects sci:sha256:7ba0bee1f809898d24fefdeb839b4d53689a26bcea0ff0429014af5f5ef0c2a9
This study uses the source hash manifest, participant data, MATLAB retrieval code, and fixed parent window rule. It checks fresh source bytes and starts, saves central five-second O1 segments, and computes new entropy scores and phase controls. It does not use the prior classifier results.
- usesdoi:10.18112/openneuro.ds004504.v1.0.9
The study analyzes processed EEG from this exact OpenNeuro release; saved metadata records version 1.0.9 and CC0.
- supportsdoi:10.3390/data8060095
The source study describes the cohort and EEG acquisition used to interpret the analyzed dataset.
- supportsdoi:10.1103/PhysRevLett.88.174102
Provides the established permutation-entropy definition used for the score.
- supportsdoi:10.1111/j.1467-9892.2007.00528.x
Provides the known Gaussian order-pattern result used for the analytic reference.
- supportsdoi:10.3390/e23070787
Provides prior evidence about filtering and interpretation of permutation entropy, cited in the limitations.
- supportsdoi:10.3389/fphys.2018.01350
Provides prior EEG surrogate evidence about endpoint matching, cited in the limitations.
- doi:10.1109/ACCESS.2023.3294618
Cited for source-dataset credit as requested by the saved dataset metadata; the present study does not use its model or predictions.
- doi:10.1007/s11571-026-10464-w
Cited for source-dataset credit as requested by the saved dataset metadata; the present study does not estimate machine-learning accuracy.
Cited by
2 publicationsPublic catalog entries on Sciscape.
- usesThe 95% interval included zero for the 10 ms Gaussian entropy residual contrast in 25 screened ds005420 v1.0.0 pairs with the source reference
This related EEG study informed the discussion of finite Fourier controls and window endpoint limits. We reused no code, signal, or result table.
- usesMean 2–30 Hz O1 distance was lower at 10-second spacing than under random order within parts of 88 ds004504 v1.0.9 records with 19-channel mean referencing
This study uses the saved O1 windows, two reference arrays, source starts, and pinned source recipes. Fresh source checks reproduce all 88 records. The new calculation measures spectral time order.