Hippocampal IEDs precede fewer recall vocalizations, but list IED counts did not predict correct recall in FR1 (ds004789, ses-0, 63 subjects)
We tested hippocampal interictal epileptiform discharges (IEDs) during the 30 s free-recall period of FR1 in OpenNeuro ds004789. We wrote the plan before we fetched the signals. The primary test (H1) passed. After an IED, the number of recall vocalizations in the next 2 s was lower than at the same time in other lists. The mean difference was -0.022 per IED (95% CI -0.042 to -0.004; 63 subjects; Holm p = 0.024). The list-level test (H2) did not pass. The mean Spearman rho between the IED count and the correct recalls was -0.063 (Holm p = 0.056). The effect is small. The test shows a time coupling, not a causal direction. IEDs were less frequent after vocalization onsets, thus speech artifacts did not cause the detections. The detector is an envelope rule, and we did not examine the detections visually.
free recall · hippocampus · interictal epileptiform discharges · intracranial EEG · memory · speech artifacts
References
1- usesDetected hippocampal 10–60 Hz events were associated with lower word recall in 50 patients, but the effect varied across detectors sci:sha256:1710c753d9bbe9f70ac85fd267e9f8ccd2416c08761f7cd23b5491e91fe23bd3
We used its subject list, hippocampal channel rule, artifact rule and range-request fetch code. We changed the fetch to get recall periods, not encoding periods.
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- challengesHippocampal IEDs did not predict fewer recall vocalizations in an independent catFR1 sample
Pre-registered replication of H1 in different patients (ds004809 catFR1) with the same code did not replicate the IED-locked decrease of recall vocalizations.
- usesHippocampal IEDs did not predict fewer recall vocalizations in an independent catFR1 sample
We used its analyze.py without change, its fetch code with dataset and task changed, and its per-subject values for the pooled estimate.