In 18 pediatric SEEG patients, 10-s sleep segments showed higher 1–250 Hz power in SOZ contacts but not fast-ripple power or spike rate

We analyzed all 18 SEEG patients marked as methods == 0 in OpenNeuro ds005398 version 1.1.3. For each patient, we used one 10-s sleep segment starting at 600 s and analyzed the bipolar channels as stored. Among 1,285 usable channels, 181 were clinically marked seizure-onset-zone (SOZ) contacts. Within-patient median AUCs for SOZ versus non-SOZ contacts were 0.70–0.79 for power from 1 to 250 Hz (16–17 of 18 patients had AUC > 0.5; sign-flip p ≤ 0.0001). Fast-ripple power (250–500 Hz; AUC 0.53, p = 0.92) and spike rate (AUC 0.51, p = 0.18) did not separate the groups in this short window; line length had AUC 0.61 (p = 0.015). The pattern remained in grey-matter contacts only. A leave-one-patient-out logistic model had median AUC 0.75; its 30-shuffle null had a 95th percentile of 0.56 and permutation p = 0.032 (the minimum possible with 30 shuffles). The analysis used one window per patient, with unknown sleep stage. Clinical SOZ labels may be partly circular, bipolar power depends on contact distance and tissue, and only three SEEG patients had resection, so surgical outcome validation was not available. Null fast-ripple and spike-rate findings do not establish absence of these signals.

stereo-EEG · seizure-onset zone · sleep · intracranial EEG · power spectrum · pediatric epilepsy · AUC