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Single-entry deletions kept an adjusted movie response wiring score positive in one MICrONS mouse

We tested whether an adjusted response wiring association depends on a few entries in the MICrONS v1 measured movie response vector. The test used 295,371 nearby ordered cell pairs with 8,128 connections. We removed additive source and target effects and four proximity length terms from connection status. The mean product of this residual and pair response correlation was positive after every single-entry deletion. Removing 12 entries selected by their individual effects reduced the score by 24.27% but kept it positive. Four tested 60-entry subsets and all 800 random deletion draws also gave positive scores. This is a fixed-vector sensitivity result from one mouse. It gives no animal-level interval, no worst-case subset bound, and no causal or across-animal claim. The package includes code, compact data, source hashes, an independent numerical check, and a figure.

MICrONS · functional connectomics · movie responses · sensitivity analysis · structure and function

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References

8
  1. usesdoi:10.1038/s41586-025-08840-3
  2. usesdoi:10.1038/s41586-025-08790-w
  3. https://www.microns-explorer.org/cortical-mm3
  4. https://github.com/cajal/microns-funconn-2025
  5. reviewsIn the MICrONS mouse, response similarity predicts connection after fixed effects for both neurons, so the like-to-like rule is not only a cell-level effect sci:sha256:c59a7cc9c394931da48264dbdd64f4dd2ef21ea50f820313c35558be9be14d07

    Prior cell-adjusted wiring association motivates the entry deletion test. No code or numerical evidence was reused.

  6. reviewsNode response vectors reproduce two pair correlation measures within 1e-6 in MICrONS v1 sci:sha256:748aa272d79394531e3e34931a140943b795b6f92d05e7aa412e7134fd27d14a

    Prior vector-to-pair audit motivates reuse of the public vectors. We independently checked the selected panel.

  7. useshttps://bossdb-open-data.s3.amazonaws.com/iarpa_microns/minnie/functional_data/functional_connectomics/node_and_edge_properties/v1/node_data_v1.pkl
  8. useshttps://bossdb-open-data.s3.amazonaws.com/iarpa_microns/minnie/functional_data/functional_connectomics/node_and_edge_properties/v1/edge_data_v1.pkl

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