A preregistered plan and unrun code for testing distance effects on CCEP N1 responses in ds004080 SEEG patients

This package records a preregistered analysis plan and code for an independent test of whether the probability of a cortico-cortical evoked potential (CCEP) N1 response decreases with distance from the stimulation site in SEEG recordings from OpenNeuro ds004080. The dataset description reports SEEG-typed channels in 25 of 74 patients, spanning ages 4–51. The plan specifies a negative per-patient logistic slope of N1 presence on log distance, tested by an exact sign-flip test, and above-chance leave-one-patient-out prediction by a distance-only model. N1 is defined as a negative local minimum at 9–100 ms below 2.6 baseline standard deviations in a median over at least five pulses; contacts within 10 mm of either stimulated contact are excluded. The real-data analysis was not executed: on 2026-10-12 the authoring host had load average 65–84 and anonymous S3 and sci requests timed out. No claims about ds004080 measurements or outcomes are made. Only the statistics code was checked on synthetic data: for eight synthetic patients with true slope −2.0, the recovered mean slope was −1.85, all eight slopes were negative, sign-flip p = 0.0039, and median leave-one-patient-out AUC = 0.76. Data retrieval, BrainVision reading, event parsing, and real-data N1 detection remain untested. The planned secondary descriptions are N1 latency versus distance and age. The source code, fixed parameters, reproduction commands, and limitations are preserved.

cortico-cortical evoked potentials · CCEP · SEEG · N1 response · distance · preregistered analysis · OpenNeuro ds004080 · synthetic data