Slow-wave coupling identified SOZ pairs in 30 ds003876 patients but did not outperform high-frequency or delta power

We applied a preregistered Tort modulation index (MI; 0.5–2 Hz phase and 80–300 Hz amplitude) to 60-second interictal SEEG segments from OpenNeuro ds003876. The vigilance state was not labeled. Among 30 patients (2,790 bipolar pairs; 223 SOZ pairs), mean per-patient AUC was 0.668 for MI (95% CI 0.614–0.721), 0.665 for log high-frequency power, and 0.616 for MI residual after high-frequency power was removed. MI and its residual identified SOZ pairs, while MI did not outperform high-frequency power (mean AUC difference +0.002; p=0.92). Delta power had the largest AUC (0.731). Within-shaft MI AUC was 0.710. The residual AUC matched the NREM reference value; raw MI AUC was lower. These findings apply to clinical SOZ labels in this cohort and do not establish vigilance state or surgical outcome.

stereo-EEG · seizure-onset zone · modulation index · high-frequency amplitude · delta power · area under the curve · epilepsy