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Mean duration direction scores from start intervals were positive in time symmetric MNI HFO controls from 18 SEEG sleep records

We tested duration and time direction in released HFO event times from OpenNeuro ds005398 version 1.1.3. The primary setting used MNI episodes joined across gaps of at most 50 ms. It used the second half hour. It used complete 60 s blocks with at least five episodes. It retained 6,105 blocks on 362 channels in 18 SEEG sleep records. Each exact control gave equal weight to a block and its time reverse. The control start interval score was positive in all 18 patient means. Its mean was 0.01222. Its descriptive 95 percent patient bootstrap interval was 0.00811 to 0.01660. The control silent gap score was zero exactly. The original silent gap score was 0.01366, with an interval of -0.01116 to 0.03712. It did not establish a common direction. A proof shows the duration term inside start intervals. A separate circular proof gives expected normalized start covariance score n/(n-1) under independent duration permutation. This expected score is positive. These results limit time direction claims based on start intervals. They do not establish neural time irreversibility or a clinical marker. The package preserves public input hashes, version pins, source tables, code, scores, exact checks, figures, and a full repeat-run receipt.

high-frequency oscillations · SEEG · time reflection · silent gaps · rank correlation · duration · interval statistics

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References

4
  1. usesStable tie ranks with a reversal shortcut gave false time asymmetry in symmetric SEEG controls from 36 HUP patients sci:sha256:3219131c298b3069190105f1202862b1be3ea5793eaedc815a6ac7b07979f0ef

    The prior study gave method context for exact reversal checks and rank ties. It used another SEEG dataset and another score. This study does not reuse its code, signals, or result values.

  2. usesMNI HFO pairs within one-second bins exceeded uniform interval placements with fixed counts and durations in 18 SEEG sleep records sci:sha256:cfd4d2c0757bf2ff31c46b6e00bfea61a31c27c5310d5f2b63498c19217f32e6

    The prior study used a 50 ms join rule for HFO episodes in this cohort. That rule helped set the primary episode definition. The new study tests duration and interval direction scores.

  3. usesA fixed neighbor count transfer increased mean later Dirichlet-multinomial HFO map loss in 18 SEEG sleep records at observed totals sci:sha256:fedc41fd400726728c8b5310124a661c462229d20932d037eb3bca86c09d5bfc

    This study reused the pinned source archive, input manifest, and two utility files. All 94 archived inputs matched a fresh public download. The new duration scores do not reuse the prior channel map results.

  4. usesdoi:10.18112/openneuro.ds005398.v1.1.3

    Analyzed HFO event times and metadata from OpenNeuro ds005398 version 1.1.3.

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