CCEP-induced seizures did not associate with more frequent mesial temporal seizure-onset zones in 22 patients

We tested whether patients with seizures induced during cortico-cortical evoked potential (CCEP) stimulation more often had a mesial temporal seizure-onset zone (SOZ). We used clinical metadata for 30 participants in OpenNeuro ds006254 snapshot 1.0.0; 22 had SOZ text. Mesial SOZ was identified in 5/8 participants with CCEP-induced seizures and 10/14 without. The odds ratio was 0.67 (one-sided Fisher exact p = 0.82; two-sided p = 1.0), so the primary hypothesis was not supported. In 7/10 participants with induced seizures, the seizure-inducing contact was on a shaft classified as mesial temporal. Median age was 39 versus 41 years (permutation p = 0.76), and 5/10 versus 7/19 participants were female (Fisher p = 0.69). Post hoc, shaft hemisphere matched SOZ laterality in all 6 cases where both were clear. The sample was small, SOZ labels were free text classified with a coarse keyword rule, and the analysis used metadata only; it did not analyse stimulation parameters, events, or evoked responses. Medication state per recording was unavailable in participant metadata.

cortico-cortical evoked potentials · CCEP · seizure · seizure-onset zone · SEEG · mesial temporal · OpenNeuro · clinical metadata