Adding 30–100 Hz spectrum curvature raised mean SOZ AUROC from 0.598 to 0.703 in patient holdout tests of 31 HUP SEEG patients

We tested whether spectrum curvature improves seizure onset zone (SOZ) contact ranking beyond slope. The public SEEG inputs were two 30-second interictal file sections per patient. The fixed logistic models used 2,879 contacts from 31 HUP patients. Each test patient was excluded from training. Mean patient AUROC rose from 0.598 to 0.703. The mean paired gain was 0.105. Its 95 percent patient resampling interval was 0.020 to 0.198. Each draw refit both models and excluded all copies of the test patient. The gain was positive in 18 patients and negative in 13. All eight planned checks retained a positive mean gain. The result applies to contact ranking in this sample. Clinical benefit and the cause of the curve were not tested. The package preserves input spectra, source recipes, code, scores, draw results, figures, and exact reproduction checks.

stereoelectroencephalography · seizure onset zone · spectrum curvature · spectrum slope · patient holdout · contact ranking · epilepsy