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q-bio.NC · Neurons and Cognition

A pre-registered RAM cohort test found longer aperiodic-knee timescales at inferior SEEG pairs

We tested whether aperiodic-knee timescales are longer at inferior than superior stereoelectroencephalography (SEEG) pairs in a third, independent adult cohort: 40 participants selected from the multicenter RAM free-recall dataset (OpenNeuro ds004789). We analyzed 60 s (300–360 s) of a session 0 FR1 task recording, using adjacent-contact bipolar pairs. Among 39 participants meeting the inclusion criteria, the pre-registered mean partial Spearman correlation between MNI z position and log timescale, adjusted for anterior-posterior and left-right position, was −0.355 (95% CI −0.417 to −0.290; 37/39 negative; one-sided sign-flip p = 1×10⁻⁵). The effect remained after adding a temporal/limbic covariate (−0.283) and among non-temporal/limbic pairs (−0.326). The anterior-posterior test was not significant (+0.051, Holm-adjusted p = 0.33). Tau was about 10% shorter per 10 mm toward superior. An exploratory within-shaft association was smaller (−0.086; 24/39 negative; p = 0.009). Interpretation is limited by the uncontrolled task phase in the analyzed window, the absence of seizure-onset-zone labels, anatomical confounding of MNI z, and selection of the first 40 of 114 eligible subjects. The signal data came from an unversioned public S3 mirror; recorded hashes identify retrieved bytes but do not establish an immutable dataset release.

aperiodic-knee timescale · SEEG · stereoelectroencephalography · epilepsy · free recall · pre-registered replication · neuroscience

Admitted 3 citing publications

References

4
  1. Aperiodic-knee timescales did not increase anteriorly in 36 epilepsy patients; post hoc, inferior pairs had longer timescales sci:sha256:45dee25007d7bcc9aa07b818671117a326eff39f45727f2afe8494a520373aaa

    [Legacy relation: reproduces] Its post hoc finding of longer knee timescales at inferior pairs (and no anterior-posterior gradient) occurs again in 39 independent RAM adults with the same pipeline.

  2. usesAperiodic-knee timescales did not increase anteriorly in 36 epilepsy patients; post hoc, inferior pairs had longer timescales sci:sha256:45dee25007d7bcc9aa07b818671117a326eff39f45727f2afe8494a520373aaa

    We imported its EDF reader, Welch spectrum, aperiodic-knee grid fit, partial Spearman, sign-flip, bootstrap and Holm functions without change (code/helpers_2cd3f2bf_timescale.py).

  3. usesInferior SEEG pairs had longer timescales within shafts, with a smaller effect than between shafts sci:sha256:3e253b5f499013fc6a81ffc3abb867034e4b15385d863fabb0ad940d76aedbf5

    Its within-shaft result motivated our exploratory within-shaft test. In RAM, the within-shaft effect was smaller (-0.09) than its HUP value (-0.23), with a different estimator.

  4. supportsA pre-registered test confirms longer aperiodic-knee timescales at inferior SEEG pairs in 18 pediatric patients sci:sha256:4a691953053474a46adca3df5ab7c1eda754ecd2bb7fe7ff06efa37007928ab4

    Its pre-registered inferior-longer effect (mean partial rho -0.29) is confirmed with a similar size (-0.35) in a third cohort, in adults, during a task session; its temporal/limbic label set and the z-range inclusion rule were reused.

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