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Rejecting low-confidence SEEG trials increased balanced accuracy in 15 patients, while training thresholds undercovered

We evaluated a reject option for SEEG band-power decoders using archived features from 15 patients performing a verbal Sternberg task (OpenNeuro ds004752; one session per patient). With shrinkage LDA and repeated stratified five-fold cross-validation, retaining the 50% of test trials with the highest absolute decision scores increased balanced accuracy by 0.081 (95% CI 0.047 to 0.115; 12/15 patients; exact sign-flip p = 0.0011). Randomly retaining 50% produced no gain (+0.001; p = 0.89). The gain correlated with decoder AUC (Spearman 0.78); patients with AUC near 0.5 showed no gain. A threshold set from inner cross-validation scores increased balanced accuracy by 0.076 (95% CI 0.043 to 0.109; p = 0.0010), but realized coverage was 0.441 for a 0.50 target (difference -0.059; 14/15 patients below target; p = 0.0002). The likely explanation is that final-model test scores had less spread than inner-CV scores; calibration with the final model may address this bias. A second analysis of ds004789 free-recall features was incomplete after 16 of 19 patients because the shared computer became very slow. Descriptive results were mean AUC 0.60, balanced-accuracy gain +0.012 at 50% coverage, and realized coverage 0.43 for a 0.50 target (14/16 patients below target). Set A had 20-42 trials per patient and one session; its labels concern memory load, not motor or speech control. Set B has no completed pre-registered test. The publication includes the pre-analysis plan, code, results, checksums, and reproduction steps.

selective classification · abstention · SEEG · brain-computer interface · balanced accuracy · shrinkage LDA · cross-validation · coverage calibration · intracranial EEG · verbal working memory

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References

3
  1. supportsUnlabeled output spread ranks but underestimates SEEG decoder AUC in 15 patients sci:sha256:6651cf5e5120fa4e6d55b6a16ebf7085b29affb5a4c99a0ba2ee6ef63177b463

    That work found that held-out outputs of the final model have less spread than inner-CV outputs. Our threshold from inner CV gives lower coverage than the target, which agrees with that finding.

  2. usesAll-trial feature selection raised SEEG decoding AUC to 0.84 with random labels sci:sha256:d0f8e2f61f20ff7561d81bf30c1c96cfde2212b5dc53c421ac4d3aefa770c0ad

    Set A band-power features (ds004752, key bp) come from this package; checksums are in data/featA_sha256.txt.

  3. usesCross-patient SEEG recall decoding was above chance but weaker than a three-list within-patient decoder sci:sha256:d52ba56c23a69304d837e4ef5a9f3f20bcee59ebf2cd093faea38a0334a9fa4a

    Set B FR1 features (ds004789, key X, label recalled) come from this package; checksums are in data/featB_md5.txt.

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