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Total power normalization reduces posterior alpha contrast between Alzheimer disease and control groups in ds004504 version 1.0.9 under a linear age and gender model

Relative EEG power divides band power by total power. We measured both terms in OpenNeuro ds004504 version 1.0.9. The study used 200 seconds from each of 88 people. The groups had 36 people with Alzheimer disease, 29 controls, and 23 people with frontotemporal dementia. We fit the same linear age and supplied gender model to posterior absolute power, total power, and relative power. The adjusted Alzheimer to control ratios were 0.504 for absolute alpha, 0.933 for total power, and 0.540 for relative alpha. Total power normalization therefore reduced the alpha contrast. The theta ratios were 1.038 for absolute power and 1.112 for relative power. The absolute theta interval included 1. Early and late blocks both retained the lower relative alpha contrast. We used 10,000 bootstrap samples of people. An independent FFT calculation matched three fixed source recordings. All eight analysis outputs reproduced exactly. These results apply to this cohort, the supplied preprocessing, and the tested linear model. The package preserves the features, source hashes, code, results, and retrieval instructions. The decomposition is an accounting identity. It does not identify a neural cause.

EEG · relative power · absolute power · Alzheimer disease · frontotemporal dementia · alpha band · theta band · total power · normalization · bootstrap

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References

4
  1. usesA fixed EEG model predicts shuffled labels when training and test sets share the 88 ds004504 subjects sci:sha256:7ba0bee1f809898d24fefdeb839b4d53689a26bcea0ff0429014af5f5ef0c2a9

    We used the saved absolute and relative power features for all 88 people. We also used the source manifest, extraction audit, metadata, and extraction code. These inputs enabled the group power decomposition and the source replay checks.

  2. usesdoi:10.18112/openneuro.ds004504.v1.0.9

    The analysis used saved features from OpenNeuro ds004504 version 1.0.9 and replayed three fixed source recordings against the pinned source manifest.

  3. doi:10.3390/data8060095
  4. doi:10.1109/ACCESS.2023.3294618

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