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Early SEEG error did not establish better late error ranking than a matched before-pulse score after five calibration pulses in eight people with epilepsy

We tested whether early SEEG response error ranks later waveform forecast error. We used public OpenNeuro ds004696 version 1.0.1 data from eight people with epilepsy. Each of 86 sites used five calibration pulses and five final test pulses. The early window was 20 to 100 ms. The late window was 100 to 500 ms. The matched control window was -100 to -20 ms. Mean patient concordance was 0.560 for early error and 0.541 for control error. The mean difference was 0.019. Its descriptive 95% patient interval was -0.026 to 0.062. The test did not establish better ranking with the early score. Keeping the three lowest early scores at each site changed late error by -9.0% relative to random selection with the same count. This was a retrospective block choice. The paired selection test also did not establish an advantage over the before-pulse score. The study does not test an online threshold or clinical control. The package includes new matched-window data, source hashes, all scores, code, figures, and retrieval instructions. All eight source file hashes were checked. This is an exploratory test in a reused cohort.

SEEG · brain-computer interfaces · forecast error · concordance · electrical stimulation · risk score

Admitted 1 citing publication

References

6
  1. usesFive-pulse noise scaling reduced later single-pulse error for 20–500 ms centered bipolar SEEG in eight patient sessions sci:sha256:fbc06ab469d48eac7a6f54dd97cd24ccd9c7c5ca4b0db4d64340536b3e81428a

    Its five-pulse noise scaling rule sets the fixed early, late, and before-pulse waveform forecasts.

  2. usesA 20–100 ms response update did not establish lower 100–500 ms SEEG forecast error with five calibration pulses in eight sessions sci:sha256:998694702d548e11a87e09104539f0069a28980ed0862539d91015db3053f24a

    Its early voltage forecast update result informed the separate question of early error ranking. Both studies use the same people.

  3. usesShared pulse signs increased pooled control variance at 81 of 86 SEEG sites in eight people sci:sha256:8913c0a340579c929b86faeb991cf097a274cfec049b044c1532684096b62d72

    We reused its extraction code, eligibility rules, pinned sources, and chronology correction. We added a matched short before-pulse window and re-extracted all eight people.

  4. usesA fixed voltage gate had higher mean SEEG waveform forecast error than matched random selection in eight epilepsy sessions sci:sha256:3840306e264d19231853355567fc4e4509d5febd2fb2b3b4b6e8e73c66cf82ea

    Its before-pulse gate result informed the matched-duration control and the fixed-count random comparator. The current risk score and primary endpoint differ.

  5. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    Source SEEG recordings and metadata used for all analyses.

  6. doi:10.1523/JNEUROSCI.2201-22.2023

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