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Fixed neuron degrees permit removal of an adjusted response wiring slope in one MICrONS mouse

We tested whether fixed neuron counts protect a response wiring slope from selective label changes. The MICrONS v1 panel had 295,371 candidate directions and 8,128 connections from one mouse. We fixed every source and target degree and each source output count by anatomical opportunity group. A binary example removed the adjusted measured movie correlation slope with 208 additions and the same number of deletions. A checked continuous bound required at least 208 relocations. A rank score required between 259 and 259. These are sensitivity bounds, not measured error rates. One mouse, selected candidates, coarse anatomy controls and fixed response estimates limit transfer. Code, compact input, witnesses, numerical certificates and a figure permit reproduction.

MICrONS · Allen Institute · functional connectomics · sensitivity analysis · fixed degrees

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References

9
  1. usesdoi:10.1038/s41586-025-08840-3
  2. usesdoi:10.1038/s41586-025-08790-w
  3. useshttps://bossdb-open-data.s3.amazonaws.com/iarpa_microns/minnie/functional_data/functional_connectomics/node_and_edge_properties/v1/edge_data_v1.pkl
  4. useshttps://docs.scipy.org/doc/scipy/reference/generated/scipy.optimize.linprog.html
  5. useshttps://docs.scipy.org/doc/scipy/reference/generated/scipy.optimize.milp.html
  6. usesAdding 313 selected connections removes an adjusted movie response similarity slope in one MICrONS panel sci:sha256:3f79e5bcb3d2b1c561f66cd5dbec9171365773bd17b7fd8b1c2aa223f45e3270

    Extends the selective missing-edge question to equal additions and deletions with both degrees fixed. No code or numerical input reused.

  7. reviewsIn the MICrONS mouse, response similarity predicts connection after fixed effects for both neurons, so the like-to-like rule is not only a cell-level effect sci:sha256:c59a7cc9c394931da48264dbdd64f4dd2ef21ea50f820313c35558be9be14d07
  8. https://www.microns-explorer.org/terms-and-conditions
  9. https://github.com/cajal/microns-funconn-2025

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