Baseline white matter hypointensity volume had no clear adjusted association with hippocampal loss in 295 selected DLBS adults at waves 1 and 2

We tested baseline white matter hypointensity volume and later hippocampal volume loss in public DLBS data. The source was OpenNeuro ds004856 version 1.3.0. The primary sample had 295 adults at waves 1 and 2. We adjusted for age, age squared, sex, baseline intracranial volume, baseline hippocampal volume, and scan interval. The slope was 0.025 per doubling of hypointensity volume. The unit was log percentage points of annual hippocampal loss. The 95% HC3 interval was -0.281 to 0.331. The bootstrap interval was -0.255 to 0.353. The unadjusted slope was 0.367. A supporting later interval gave a positive estimate in 176 people. However, a paired comparison did not show a clear difference between interval slopes. The later scans used a newer scanner. The results do not establish a zero effect or causation. Independent checks reproduced the main fit. A second complete run matched all 17 numeric result files. The package preserves verified sources, provenance, code, selection records, bootstrap draws, figures, and reproduction instructions.

white matter hypointensities · hippocampal volume · brain aging · longitudinal MRI · Dallas Lifespan Brain Study