Interictal 80-150 Hz power and interictal spike rate each identify SOZ pairs after linear within-patient control for the other (59 patients, ds004100 and ds003876, 120 s bipolar)
In 59 patients from two OpenNeuro SEEG cohorts, we calculated per-patient AUC for clinical SOZ pairs. Each feature was the residual after a linear within-patient fit on the other feature. HFA given spike rate had mean AUC 0.645 (95% CI 0.602-0.688). Spike rate given HFA had mean AUC 0.673 (95% CI 0.617-0.726). Both Holm p values were 1e-4. The two features had a small correlation (mean rho 0.08). Control for spike rate decreased the HFA AUC by only 0.022. Thus, the two features give mostly independent SOZ information. The plan was hashed before the analysis.
seizure-onset zone · high-frequency activity · interictal spikes · intracranial EEG · area under the curve · epilepsy
References
5- usesThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615
Origin of the ds004100 HUP per-pair HFA and spike-rate table.
- usesIn 117 SEEG patients, the top interictal HFA pair was in the clinical SOZ less often than its AUC predicted sci:sha256:6c85dc6f3540bdd41aaeb79a7fbecee27e8b50ac476c990e8241c271ddd4e414
Source of the two archived per-pair feature tables.
- usesAcross 29 SEEG patients, the 30–45 Hz exponent did not separate SOZ channels, while four other features did sci:sha256:115bc8cb0b4c9e536b5f083843a2745508d3c6635a8156b661a9e084f51582a7
Origin of the ds003876 per-pair HFA and spike-rate table.
- usesdoi:10.18112/openneuro.ds004100.v1.1.3
The archived HUP per-pair feature table used in the analysis is attributed to OpenNeuro ds004100.
- usesdoi:10.18112/openneuro.ds003876.v1.0.2
The archived four-center per-pair feature table used in the analysis is attributed to OpenNeuro ds003876.
Cited by
1 publicationPublic catalog entries on Sciscape.
- supportsIn 32 HUP SEEG patients, 60-Hz line-noise excess was lower on SOZ pairs and did not explain high-frequency separation
The 80-150 Hz SOZ separation in ds004100 is not explained by line-noise excess. LNX is lower on SOZ pairs and has a negative correlation with HFA.