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q-bio.NC · Neurons and Cognition

Non-SOZ high-gamma power was not higher in the SOZ hemisphere in HUP patients

We tested whether interictal activity at non-seizure-onset-zone (non-SOZ) bipolar pairs is higher in the clinical seizure-onset-zone (SOZ) hemisphere than at mirror-matched contralateral positions. We analyzed archived 120-s interictal features and fsaverage electrode coordinates from 18 eligible HUP patients in OpenNeuro ds004100. For the primary analysis, 17 patients had valid 80–150 Hz high-frequency activity (HFA) values: the mean ipsilateral-minus-contralateral difference was −0.041 log units (95% CI −0.109 to 0.016; 7/17 positive; one-sided permutation p=0.88). Spike rate, line length, and 1–40 Hz power showed no significant matched asymmetry after Holm correction. The higher matched non-SOZ value identified the SOZ side in 7/17 patients for HFA and 11/18 for spike rate, not better than chance. Without matching, HFA was lower on the SOZ side (AUC 0.425, 95% CI 0.371–0.475); this unplanned result is exploratory. In a remote-pair analysis, 1–40 Hz power had a weak increase (95% CI 0.011–0.237; Holm p=0.083), which needs testing in a larger cohort. The sample was small and left-biased (15/18 left SOZ), so the study cannot separate a SOZ-side effect from a general hemispheric difference. Other limitations include clinical SOZ labels, short clips, template coordinates, and clinical sampling bias. Two patients sampled at 256 Hz lacked HFA values and were excluded from HFA tests.

stereo-EEG · epilepsy · seizure onset zone · interictal activity · high-frequency activity · hemisphere · mirror matching

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References

4
  1. usesTissue matching did not reduce the interictal HFA SOZ AUC in 32 HUP patients sci:sha256:6964c98440fff441ef838b3074e9cb4ab68166c3e025af5fac5763d445ed09c1

    We use the archived per-pair feature table and the fsaverage electrode files from this package.

  2. usesThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615

    This work computed the interictal per-pair features that we analyze.

  3. supportsInterictal spike rate decreases with distance from the SOZ in 31 HUP SEEG patients; HFA and line length do not sci:sha256:bfa2d6cfe9e85695b79477b5ab90e928d04327b5bd5cd74542c2a2c6e65ac98e

    That work found that non-SOZ spike rate falls with distance from the SOZ but HFA does not. We find no hemisphere-level non-SOZ HFA increase on the SOZ side, which agrees with a local, not hemispheric, effect.

  4. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    This study uses HUP ds004100 channel annotations and fsaverage electrode-coordinate files. The archived feature table was computed from these data, and the coordinate files were retrieved from the dataset.

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