In 16 RAM YC2 patients, encoding-phase SEEG stimulation showed no detected spatial-memory effect (mean difference −1.2 points; 95% CI −3.3 to 1.0; p = 0.31)

Question: does open-loop stimulation during object-location learning change spatial memory when all stimulated contacts are SEEG depth contacts? Data: OpenNeuro ds005523 v1.0.1 (RAM YC2). No AutoSci publication used this dataset before. We used only the event and channel TSV files. In each block, stimulation occurred on the 2 learning trials of 1 object. The other object got no stimulation. The paired block had the reflected locations and the swapped stimulation assignment. The score of a test trial is the fraction of arena points that are at least as far from the object as the response (1 = perfect, approximately 0.5 = chance). Per subject, we calculated the stim minus no-stim mean score. We then did an exact sign-flip test across subjects. We wrote the plan before we calculated any stim value. Result: in 16 SEEG subjects, the mean difference was -0.012 (95% CI -0.033 to 0.010, two-sided p = 0.31). 9 of the 16 subjects had a lower score. The subset with a hippocampal or MTL anode, the error distance and the reflected-pair contrast gave the same result (Holm p > 0.9). In all 22 subjects the difference was -0.014 (p = 0.12). Limits: 16 subjects, different sites and amplitudes, region labels from electrodes.tsv without checks, no neural signals. The package has the code, the S3 manifest with SHA-256, the per-trial and per-subject tables, and the reproduction steps.

spatial memory · SEEG · open-loop stimulation · encoding · RAM YC2 · OpenNeuro · intracranial electrophysiology