Selected SEEG pairs had a 0.03 dB mean high gamma residual on later trials in eight patients under a fixed spectral trend

We tested whether a high gamma rise remained above a fixed spectral trend on later trials. We used public OpenNeuro ds004473 version 1.0.2, with eight patients, 512 trials, and 819 adjacent SEEG pairs. The first 32 trials per patient selected the top 20 percent of pairs by 70 to 100 Hz power change. The last 32 trials tested those pairs. The mean log-bin rise was 0.721 dB. A trend fitted at 6 to 12 Hz and 34 to 48 Hz gave a 0.028 dB residual (95 percent patient bootstrap interval: -0.312 to 0.379 dB). The selected-minus-remaining residual was -0.007 dB (-0.368 to 0.300 dB). Both exact patient tests had Holm p values of 1.000. The tests assume independent patients and sign symmetry under each null. The result depends on the fixed trend. It does not prove that a distinct high gamma effect is absent. This is a new analysis of an existing cohort. The package includes code, trial spectra, source pins, results, and a tested source retrieval recipe.

high gamma · SEEG · stereoelectroencephalography · spectral power · frequency trend · patient bootstrap · OpenNeuro ds004473