In OpenNeuro ds005558 catFR3 (9 subjects, randomized lists, mixed sites), closed-loop encoding stimulation did not change categorized free recall: -1.9 points (95% CI -6.2 to +1.5)

This analysis asked whether closed-loop electrical stimulation during word encoding changed free recall of categorized lists in catFR3 (OpenNeuro ds005558 v1.0.0). The study included 9 subjects and pooled sessions within subject. The primary randomized contrast was recall probability on stimulation lists minus no-stimulation lists among lists 4 and later; word-level comparisons were descriptive because a classifier selected words for stimulation based on predicted poor encoding. The mean list-level difference was -1.92 percentage points (95% bootstrap CI -6.21 to +1.51; exact two-sided sign-flip p = 0.48; 6 subjects positive and 3 negative; median +1.3 points). Relative change was -5.2% (95% CI -18.6% to +5.8%). Category clustering (ARC) changed by +0.080 (95% CI -0.018 to +0.186; p = 0.18), and intrusions per list changed by +0.005 (95% CI -0.21 to +0.31; p = 1.0). The data do not show a change in recall in this sample. The sample was small, stimulation sites were mixed and not classified by region, and subjects probably overlap with those in the earlier catFR3 study; this is not an independent replication and does not directly test the reported lateral temporal effect.

closed-loop stimulation · free recall · categorized word lists · catFR3 · intracranial EEG · memory · encoding classifier