In 32 HUP SEEG patients, SOZ pairs separated within shafts, but contact depth alone matched high-gamma power
Using archived interictal bipolar-pair features and clinical seizure-onset-zone (SOZ) labels from HUP SEEG data (OpenNeuro ds004100 v1.1.3), we tested whether features distinguish SOZ from non-SOZ pairs on the same shaft. In 32 eligible patients, the preregistered within-shaft AUCs were 0.649 for spike rate, 0.774 for high-gamma power, 0.736 for line length, and 0.728 for delta power (Holm-adjusted p = 0.0002 for each). A second clip run showed the same pattern. Exploratory analysis found that contact depth alone yielded AUC 0.787. After linear adjustment for depth within each shaft, AUCs fell to 0.543–0.617 in run-01 and 0.553–0.631 in run-02, while remaining above chance (p ≤ 0.047 in both runs); high-gamma retained the largest depth-adjusted separation. Thus, most observed within-shaft separation followed contact depth, with a smaller depth-independent component. This single-center study uses clinical labels, short interictal clips, and no tissue labels; the data cannot distinguish tissue-type effects from epileptogenicity effects.
stereo-EEG · epilepsy · seizure onset zone · interictal activity · high-gamma power · contact depth · area under the curve · HUP · OpenNeuro ds004100
References
4- usesIn 36 HUP SEEG patients, region matching reduced high-gamma and line-length SOZ separation; spike-like rate remained sci:sha256:2057f2f243aeb5675d28b8c2722da8e27f5cf10ddbf3d7ec49c54801406d10e6
Input per-pair feature tables (run-01 and run-02) are the archived files of this publication.
- supportsShort interictal HFA did not rank SOZ shafts in 71 patients, despite higher pair-level HFA sci:sha256:87dee5aec306eee9fd5185710a8648547fd96012908b1e5f1e68682f82423179
Between-shaft high-gamma AUC here is near chance (0.57), which agrees with the finding that shaft-mean HFA does not rank SOZ shafts; separation is at contact level and is mostly linked to depth.
- usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1
The per-pair features were computed by this publication from ds004100.
- usesdoi:10.18112/openneuro.ds004100.v1.1.3
The archived bipolar-pair features analyzed here were computed from HUP SEEG interictal clips and clinical SOZ labels in OpenNeuro ds004100 v1.1.3.
Cited by
2 publicationsPublic catalog entries on Sciscape.
- Contact depth separated SOZ pairs, while high-frequency activity retained within-shaft signal after adjustment in two cohorts
[Legacy relation: reproduces] Pre-registered test of the exploratory 902c2c54 depth-adjusted within-shaft SOZ AUC in two other cohorts; same AUC definition and linear depth adjustment. The HFA result agrees (adjusted AUC 0.63 vs 0.62-0.63 for high-gamma in HUP; depth AUC 0.73 vs 0.79).
- Within SEEG shafts, depth separated SOZ pairs, while depth adjustment modestly reduced HFA separation across three cohorts
[Legacy relation: reproduces] Pre-registered test of its exploratory depth claims in 3 independent cohorts. The depth AUC replicated (0.68 vs 0.79). The decrease after depth adjustment was smaller (0.06 vs 0.16).