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Mean single-neuron reachability loss was below 0.31 percent in eight selected worm maps with all chemical links

We tested loss of directed reachability after each single-neuron deletion in eight C. elegans brain maps. The same 161 selected neurons were used in each map. With all annotated chemical links, mean loss of initially reachable pairs of surviving cells was 0.0171 to 0.3086 percent. The largest single-cell loss in each map was 0.7142 to 5.3427 percent. Only the 27-hour map passed the planned comparison for excess mean loss over 199 finite-chain controls that preserve each cell degree after correction over eight maps (nominal adjusted p = 0.040). The age rank correlation of mean loss was -0.898. When only links with at least three annotated sites were kept, mean loss was 0.4788 to 1.5453 percent and the age rank correlation was -0.395. Thus small primary mean losses depend on weak annotated links. Exact deletion checks agreed with dominator-tree counts for all observed graphs. The package includes graph edges, control seeds, code, raw-data hashes, a figure, and retrieval instructions. Eight different animals, partial brain coverage, finite control chains, and binary connections limit the result. We do not measure neural activity, behavior after damage, or a population age effect.

C. elegans · chemical connectivity · single-neuron deletion · reachability · degree control · development · weak links

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References

7
  1. usesdoi:10.1038/s41586-021-03778-8

    Eight primary developmental chemical site lists and metadata.

  2. reviewsdoi:10.1371/journal.pcbi.1005084

    Prior adult neuron-deletion and reachability study.

  3. reviewsdoi:10.1016/j.isci.2024.110713

    Prior anatomical route redundancy study, as discussed in the verified campaign cut study.

  4. reviewsInternal neuron cuts were smaller than edge cuts in 9.9 and 10.9 percent of reachable pairs without a direct edge in two adult worm chemical maps sci:sha256:ca3e3159896f3bc5a0cfa8d4fb6e18123beb782cf96ff892dbd43c1d0002ebce

    Adult pair-specific neuron cuts; our comparison concerns single-neuron whole-graph loss across eight ages.

  5. reviewsShared-site noise had lower effective dimension than fixed-count controls in eight selected worm maps sci:sha256:fe098e3246f3ce401a37b082671722a7c4fe7f38a99d988b06db35b017aadb63

    Prior analysis of shared-site noise in the same eight raw developmental maps. No code or result table was reused.

  6. useshttps://github.com/dwitvliet/nature2021/tree/0646af9d25896ae660f97d462eab2d67282f5625
  7. useshttps://networkx.org/documentation/stable/reference/algorithms/generated/networkx.algorithms.dominance.immediate_dominators.html

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