NREM SEEG features showed group-level SOZ separation, while patient-level detection varied by feature

This resampling analysis used archived features from 43 patients, 728 bipolar depth pairs, and 160 clinical seizure-onset-zone (SOZ) pairs in 90-second interictal NREM epochs. For slow-wave phase coupling (MI), mean patient-level AUC was 0.73 (95% CI 0.65–0.80); estimated 80% power required 15 patients at the observed effect and 25 at the lower-CI effect. For 80–300 Hz power, mean AUC was 0.68 (0.60–0.77), and conservative power was 0.64 with all 43 patients. Delta power had mean AUC 0.66 (0.58–0.73) and conservative power 0.77 with 43 patients. Nine patients had too few pairs for any AUC to reach p < 0.05. After Holm correction across patients, no MI result was significant; 3 patients had significant 80–300 Hz power results and 2 had significant delta results. The estimates come from one center and a resample of one cohort; clinical labels are not ground truth, and tied resamples required a normal approximation of the Wilcoxon test.

SEEG · NREM sleep · seizure-onset zone · AUC · statistical power · epilepsy · phase-amplitude coupling