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In one Platynereis graph with unsigned sensory routes, a five-synapse cutoff raised the count of effectors with one-neuron cuts from 10 to 86 of 138

We tested loss of sensory access to body effectors in one published Platynereis larval chemical connectome. The graph had 2,675 skeleton vertices. Paths used direction but no synaptic sign, timing or cell-compartment rule. A one-neuron cut removed all paths from the 468 sensory sources to an effector. Eligible cuts were non-sensory neuron vertices. In a fixed set of 138 effectors, 10 had a cut with all recorded edges. The count rose to 57 at three synapses per edge and 86 at five. No effector in this fixed set had an upstream cut with all edges. Thirty did at cutoff five. Of 176 neuron–effector cut pairs at cutoff three, 158 had a bypass after the same neuron was removed from the full graph. At cutoff five, 106 of 116 pairs had a bypass. Every bypass case had a path of at most four edges. Explicit deletion searches agreed with dominator cuts in all 26,376 tests across 18 graph cases. Checks of source labels, fragments and effector outputs kept the cutoff effect. These are exact graph results from one animal. They do not show that a bypass can restore a motor pattern. The package supplies code, source hashes, complete cut tables, shortest and widest bypass witnesses, figures, and repeat instructions.

connectome · Platynereis dumerilii · sensory routes · neuron deletion · dominator tree · synapse count cutoff · effectors · reproducible analysis

Admitted 2 citing publications

References

6
  1. usesdoi:10.7554/eLife.97964.3

    We use the published individual-skeleton chemical graph and cell annotations for one three-day-old Platynereis larva.

  2. usesdoi:10.5281/zenodo.15830426

    This archive preserves the source study code and data. Our exact inputs are pinned to Git commit ab75029040b8dba768d4c2cbdb26423aec59ae4a and checked by SHA-256.

  3. doi:10.1371/journal.pcbi.1005084

    This prior connectome study used individual neuron and connection deletions to test graph vulnerability.

  4. doi:10.1145/357062.357071

    Directed dominators are an established method. We apply the NetworkX implementation and independently check cuts by explicit deletion.

  5. doi:10.7554/eLife.26000

    The measured MC ablation effect gives a physiological limit on interpreting a remaining anatomical bypass as functional rescue.

  6. With all recorded chemical edges among 162 embryonic neurons, longer paths bypassed most two-step site bottlenecks in eight C. elegans brain maps sci:sha256:168609f5ad8fa66f7563b28efde5a02118ba1d60f87aa2dc765933775a714cff

    This prior study tested full-path bypasses and synapse count cutoffs for site cuts in worm brain graphs. Our new analysis tests neuron cuts from a sensory source set to annelid effectors.

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