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q-bio.NC · Neurons and Cognition

In 40 epilepsy patients, spindle density at clinically normal SEEG pairs was not significantly related to daily seizures, ASM count, or age

We tested whether NREM sleep spindle density at clinically normal bipolar SEEG pairs was related to daily seizures, anti-seizure medication (ASM) count, or age in 40 epilepsy patients. The preregistered primary tests used cohort-adjusted partial Spearman correlations, within-cohort permutation tests, and Holm correction. None was significant: daily seizures r = +0.24 (Holm p = 0.304; 95% CI -0.11 to +0.54), ASM count r = +0.17 (p = 0.304; CI -0.12 to +0.41), and age r = -0.27 (p = 0.253; CI -0.58 to +0.06). The daily-seizure estimate was opposite to the predicted direction. Five preregistered secondary analyses also had p values of at least 0.13. Without spike rejection, the daily-seizure estimate changed sign, and neither estimate was significant. The confidence intervals are wide and do not exclude moderate effects. Analyses used archived features from 408 normal-normal pairs across 40 patients, derived from 180 seconds of NREM sleep per pair. Short recordings, low sample size, coarse clinical covariates, correlated covariates, and a pair-relative detector threshold limit interpretation.

sleep spindles · SEEG · epilepsy · daily seizures · anti-seizure medications · age · partial Spearman correlation · OpenNeuro

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References

6
  1. usesIn 42 patients, age was not significantly associated with NREM sigma peak frequency in normal-contact SEEG pairs after cohort adjustment sci:sha256:2b78f8ddac892863ad9e1584f99c1ef2864abcba67084ad47dcf965239c809b1

    It tested age against spindle peak frequency at normal contacts in the same datasets; we test age against spindle density.

  2. usesDetected spindle density was lower at seizure-onset-zone pairs, but the difference depended on spike rejection and was not independent of power sci:sha256:9a73db90822ffb4fe5bb99e73ff2d8306f49b99bdc7142e1906f2c30e4177124

    We used its per-pair spindle features (pairs.tsv) and its participants table as the only input data.

  3. usesNREM delta power showed no age-related decrease in bipolar SEEG contacts sci:sha256:6669abdd5b29c7f06372e78d983ecde4d6a50875d29ad5bb3dfd1aa9ed472302

    It tested age against delta and relative sigma power at normal contacts in the same datasets; we extend the test to spindle density and to two other clinical covariates.

  4. usesdoi:10.18112/openneuro.ds007118.v1.0.0

    The archived per-pair spindle features and participant covariates used in this analysis include data from this dataset version.

  5. usesdoi:10.18112/openneuro.ds007119.v1.0.0

    The archived per-pair spindle features and participant covariates used in this analysis include data from this dataset version.

  6. usesdoi:10.18112/openneuro.ds007120.v1.0.0

    The archived per-pair spindle features and participant covariates used in this analysis include data from this dataset version.

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