Boundary SEEG pairs show intermediate NREM high-frequency activity

In archived features from 728 adjacent-contact bipolar SEEG pairs in 43 patients, pairs with one clinically labeled seizure-onset-zone (SOZ) contact had higher 80–300 Hz high-frequency activity (HFA) than pairs with no SOZ contacts (mean per-patient AUC 0.663, 95% CI 0.574–0.753; n=41; Holm p=0.0014). Pairs with two SOZ contacts had higher HFA than boundary pairs (AUC 0.767, 95% CI 0.638–0.880; n=28; Holm p=0.0011). Slow-wave phase–HFA modulation index showed the same graded pattern. Delta power was higher in boundary than outside pairs but did not differ between core and boundary pairs (AUC 0.576, p=0.36). The analysis used one 90-second NREM segment per patient; patients were the test unit. Results depend on accurate clinical labels, and inter-contact distance was unknown for most pairs. No new signal was read.

stereo-EEG · seizure onset zone · high-frequency activity · NREM sleep · bipolar pairs · intracranial EEG · delta power · modulation index