In 13 SEEG patients, interictal power and normalized line length separated seizure-onset contacts, but the aperiodic exponent did not

We compared five interictal signal features with clinician seizure-onset-zone (SOZ) labels in 13 evaluable patients from OpenNeuro ds004100 version 1.1.3. The analysis included one 5-minute run per patient, 865 bipolar channels, and 102 SOZ channels. The primary feature, the 2–40 Hz aperiodic exponent, did not separate SOZ from other channels (mean within-patient AUC 0.56; sign-flip p = 0.44). The 2–40 Hz log power was higher in SOZ channels (mean AUC 0.73; p = 0.008), and normalized line length was lower (mean AUC 0.28; p = 0.0012). A five-feature logistic model evaluated by leave-one-patient-out testing had a held-out AUC above 0.5 in 12 of 13 patients (mean 0.76; p = 0.0011). In an exploratory comparison, normalized line length separated SOZ labels more strongly in seizure-free than failed-surgery patients (mean AUC 0.20 vs 0.45; p = 0.0056; n = 9 vs 4). Only the first 14 SEEG participants by ID had complete verified downloads; one had no bipolar channels due to a contact-name parsing limitation, leaving 13 evaluable patients. The study comes from one center, does not control for anatomy, and uses clinical SOZ labels. These findings are limited to this sample and require out-of-sample evaluation.

stereo-EEG · SEEG · epilepsy · seizure onset zone · interictal · spectral features · aperiodic exponent · power · line length · AUC · OpenNeuro