On average, reference choice changed 80–150 Hz power ranks more than two 20-second clips did in 33 SEEG patients

This study used public HUP SEEG data from 33 patients. It compared common average reference with local Laplacian reference. The analysis used the first 20 seconds of two interictal runs per patient. Reference choice changed 80 to 150 Hz contact power ranks more than the clips did in all patients. The mean correlation difference was 0.192, with a 95 percent interval of 0.140 to 0.248. The result remained similar in checks of clip length, channel pool, and constant signals. An exploratory comparison found different seizure onset label discrimination under the two references. The study does not establish which reference gives more accurate brain signals. The package provides code, derived data, source records, checks, and instructions for reproduction.

stereoelectroencephalography · SEEG · signal reference · common average reference · local Laplacian reference · high gamma power · contact rank · epilepsy