Division by a 30–70 Hz prediction reversed the mean seizure onset label relation for 80–150 Hz bipolar SEEG power in short samples from 34 patients

We compared measured high gamma power with its ratio to a low-band spectral prediction. We used public bipolar SEEG from OpenNeuro ds004100 version 1.1.3. The sample had 34 patients, two interictal recordings per patient, and 24 seconds per recording. The target band was 80 to 150 Hz. The prediction used a log-log fit from 30 to 70 Hz. Larger scores predicted seizure onset labels in both tests. Mean patient AUROC was 0.737 for measured power and 0.315 for the ratio. The paired change was -0.422, with a 95% patient bootstrap interval from -0.534 to -0.302. The change was negative in 30 patients. Planned reference, fit, and contact selection checks gave negative mean changes. The package preserves spectra, features, code, source versions, range hashes, results, and reproduction instructions. An independent reader checked three raw recordings. This ratio does not establish an oscillation measure or clinical accuracy.

stereoelectroencephalography · SEEG · high gamma power · spectral prediction · seizure onset zone · AUROC · power spectral density