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A fixed low frequency score added 0.034 to mean onset-label AUC above a coordinate and number model in 36 SEEG patient holdouts

We tested whether a fixed low frequency SEEG score adds information to a location and contact-number model. The source was OpenNeuro ds004100, version 1.1.3. The test used two 120-second interictal records per patient. We matched 4,209 contacts and 360 clinical onset marks in 36 patients. Each test patient was excluded from model fitting. Mean patient AUC was 0.712 for coordinates plus number and 0.746 after the EEG score was added. The mean gain was 0.034. A 95% interval from 1,000 patient bootstrap samples was 0.003 to 0.077. Each sample fitted the models again and removed all copies of its test patient from training. The lower bound is close to zero. Within 90 mixed-label shafts from 34 patients, the mean AUC change was -0.009. That secondary result has a different contact scope and no planned interval. The signal gain applies to the fixed control and supplied labels. It assumes complete onset marks and comparable source coordinate registration. Source coordinate units and reference space are unresolved. The original signal reference is unknown. This is one clinical cohort, not external validation or a test of surgery benefit. The package preserves all feature inputs, source metadata, immutable raw retrieval references, a checked raw example, code, complete results, and reproduction instructions.

stereoelectroencephalography · seizure onset labels · low frequency power · contact ranking · patient holdout · bootstrap · spatial bias

Admitted 1 citing publication

References

5
  1. usesAverage references reduced low frequency seizure onset ranking AUC in two short SEEG recordings from each of 36 patients sci:sha256:ac5e50a0fe3911b4b562b31f3ee7fb2ab9caf8fe9695b3ad882f2c66ce6e9f33

    The 72 stored-reference power files, source selection, immutable EDF object references, and extraction code supplied the signal inputs. This study adds original source coordinates, a fixed location and contact-number control, patient holdouts, and patient bootstrap model refits. The patients are the same; this is not an independent cohort.

  2. usesLower contact numbers ranked source onset marks with mean AUC 0.671 in 36 SEEG patients sci:sha256:013eb3cce926c8002b6afcff4255562722653fb99a3592d9606dfbb7f08ec19c

    The prior contact-number result motivated a fixed contact-number control. This study calculates its own contact-number input from source names and adds a coordinate model and patient bootstrap model refits. It does not reuse prior numerical predictions.

  3. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    This exact OpenNeuro release supplied the source metadata, clinical onset labels, coordinates, and the raw SEEG records underlying the archived feature inputs.

  4. supportsdoi:10.1088/1741-2552%2Fac90ed

    This study reports spatial sampling bias in onset-label prediction and motivates use of a location control.

  5. doi:10.1038/s41598-019-42347-y

    Prior background evidence on low frequency activity near seizure onset; the present score uses a different band and sampling protocol.

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