SEEG knee markers and BOLD persistence had opposite medial and lateral orders under direct MNI coordinate reuse in separate cohorts

We tested a shared anatomical ordering rule for two markers of temporal persistence. We reused task SEEG fits from RAM and measured resting BOLD persistence in a separate UCLA CNP cohort. Source MNI6 coordinates were used directly in MNI2009c space, without a warp between templates. Spatial matching retained 850 matches in 156 SEEG patients. The mean medial minus lateral log10 marker contrast was +0.243 (95% interval +0.197 to +0.288). We selected 20 fMRI records for exploration and reserved 40 for confirmation. Coverage rules retained 15 and 33 people. The reserved mean Fisher z contrast at a 2-second lag was -0.0244 (95% interval -0.0296 to -0.0193). The two markers had opposite medial and lateral orders in these separate study cohorts. The planned prediction of a shared positive order was not supported. The two primary Holm p values were 4e-05 and 4e-05. The SEEG fits were reused; this is not an independent SEEG replication. Exponent adjustment changed the SEEG contrast sign. Only 14 patients met the supplied gray-matter label rule; that interval included zero. Modality, cohort and state effects remain inseparable. The package preserves code, provenance, compact data, exclusions and negative results. These observational data do not establish causality.

SEEG · fMRI · temporal persistence · spectral knee · cross-modal comparison · spatial matching · human neuroscience