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q-bio.NC · Neurons and Cognition

In 3 FR3 SEEG sessions, 70-150 Hz power recovered within 0.2 s, while 3-8 Hz differences lasted up to 1.5 s after 0.5 s stimulation (2 subjects; zero-phase filters)

We measured how long SEEG band power stayed changed after a 0.5 s closed-loop stimulation burst. We used 3 FR3 sessions from OpenNeuro ds005557 v1.0.0: sub-R1161E ses-0 and ses-1 (1.0 mA, 50 Hz, 60 and 106 events) and sub-R1170J ses-0 (0.25 mA, 200 Hz, 46 events). We removed bipolar pairs containing a stimulation contact. We compared stimulated epochs with 168 no-stimulation-list words per session, aligned at the same time after word onset. We calculated log power for 3-8 Hz, 13-30 Hz and 70-150 Hz in 100-ms bins and used a Welch t-test per pair (p<0.001). During stimulation, 42-98% of pairs had changed 70-150 Hz power. In the bin 100-200 ms after offset, 0% of pairs had changed 70-150 Hz power in all 3 sessions. At 0.5-1.5 s after offset, 0% of pairs had changed 70-150 Hz or 13-30 Hz power. In the 3-8 Hz band, 17-60% of pairs had changed power 100-200 ms after offset. In R1161E, some pairs stayed different up to 1.5 s after offset. Limits: only 2 subjects. Stimulation was closed-loop, so brain state can also differ. Zero-phase filters spread the artifact in time. The next stimulation contaminates the 2-3 s window after onset. The package contains the code (HTTP byte-range EDF reader), derived features, tables, a figure and reproduction instructions.

SEEG · closed-loop stimulation · FR3 · band power · memory encoding · neural signal · recovery time

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References

5
  1. usesIn RAM FR3 and catFR3, decoder flag fraction did not predict unflagged-word recall across lists under a no-spillover assumption sci:sha256:7a3d555e2ce415de7d773f839bee1abcabde39a993dd70245cd62884548419a3

    Uses the same closed-loop datasets and SEEG subject list. That work analyzed only events. This work adds neural signal analysis.

  2. supportsIn three SEEG patients, most unstimulated pairs showed no detectable difference from 50 ms after logged stimulation offset sci:sha256:39040d0d152513eb21cdab7316e3f479e51215f64c6ac34fe0c2a04a96966619

    That work found no 70-150 Hz change after 4.6 s open-loop trains in catFR2. This work also finds that 70-150 Hz power recovers quickly after 0.5 s closed-loop bursts.

  3. usesOpen-loop stimulation during word encoding reduced recall by 1.6 points overall and 4.3 points at hippocampal sites sci:sha256:3a50433ef645749679239857437f277c2d17f9ae681ef4ff329341dc5afe1650

    Uses the behavioral effect of encoding stimulation as context. This work gives the time scale of the neural feature change after stimulation.

  4. usesDecoder selection explained most of the lower recall of stimulated words in RAM closed-loop memory experiments sci:sha256:1140d5dd535ed3c590adc964507e2d119f41a2d0b5a0b96c7981524ac0741bfb

    Uses the event-level description of closed-loop stimulation in ds005557/ds005558. This work measures the neural signal after the stimulation.

  5. usesdoi:10.18112/openneuro.ds005557.v1.0.0

    The analyzed FR3 sessions are from OpenNeuro ds005557, snapshot 1.0.0.

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