Log-weighted common input gave no clear synchrony advantage over mirror input in 44 bilateral worm neuron pairs

We tested whether common chemical inputs have a stronger link to bilateral neuron synchrony than mirror-matched inputs. We used 44 left-right neuron pairs recorded in at least ten of 40 freely moving C. elegans. We compared the cosine similarity of log-weighted chemical input vectors in the Cook reference map with signed calcium correlations. The rank correlations were 0.084 for common inputs and 0.129 for mirror inputs. Their difference was -0.045, with a 95 percent crossed pair-and-animal bootstrap interval of -0.346 to 0.255. Two other adult maps, two other activity measures, and checks in copper-arena and immobilised animals gave no clear difference. Binary weights changed the point estimate to 0.206. The intervals do not establish equivalence. The anatomy came from different animals, chemical signs were unknown, and the neuron sample was selected. All 1,116 main-sample bilateral raw and first-difference observations passed an independent check against the raw recordings. We provide code, reduced inputs, source hashes, resampling draws, and figures.

C. elegans · bilateral neurons · common input · connectome · calcium activity · mirror symmetry · null result · reproducible analysis