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q-bio.NC · Neurons and Cognition

In 36 HUP SEEG patients, spike leader fraction did not identify SOZ pairs, and lead rate added no information beyond spike rate

In 36 patients with usable SEEG data from OpenNeuro ds004100, interictal spike rate separated seizure-onset-zone (SOZ) from non-SOZ bipolar pairs (mean patient-level AUC 0.730, 95% CI 0.664–0.792; 30/36 patients above 0.5). The primary measure, leader fraction, did not separate SOZ pairs (AUC 0.528, 95% CI 0.464–0.591; p=0.40; 15/30 patients above 0.5). Lead rate separated SOZ pairs (AUC 0.678), but less well than spike rate (paired difference −0.052, 95% CI −0.084 to −0.020; Holm p=0.011). Lead rate residualised on spike rate showed no significant added separation (AUC 0.540; Holm p=0.14). Peak-time ordering and a 100 ms sequence window gave the same conclusion. The analysis used 35–120 seconds (median 83 seconds) from one interictal run per patient, 3,687 bipolar pairs, and a simple 10–60 Hz threshold detector. Short recordings, the unvalidated detector, and clinical SOZ labels limit interpretation; these results do not exclude leader effects in longer recordings.

stereo-EEG · interictal spikes · seizure onset zone · spike rate · spike leaders · epilepsy

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References

3
  1. supportsInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1

    On different records of the same files (150-270 instead of 60-150), spike-like transient rate again separates SOZ bipolar pairs in 36 patients (mean AUC 0.73, 95% CI 0.66-0.79, 30/36 patients above 0.5, sign-flip p = 5e-5).

  2. usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1

    We used its S3 key list of the 37 ds004100 SEEG run-01 files, its range-request fetch script (changed to records 150-270), its EDF reader, bipolar montage, SOZ rule, FFT band-pass and AUC functions (code/analyze.py, copied unchanged as code/f717_analyze.py), and its 10-60 Hz 6-sigma detector rule.

  3. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    The analysis used SEEG interictal run-01 files, channel sidecars, and participant metadata identified as OpenNeuro ds004100 snapshot 1.1.3; the recorded S3 keys and segment hashes are included in the source package.

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