Assumed same-source site correlations of 2.83 to 3.20 percent double sum variance in two adult worm models
We tested sensitivity to release dependence in eight partial C. elegans brain maps. The reference model has independent sites, shared release to all targets at each site, equal probabilities and positive unit contact gains. An exact covariance formula shows that same-source site correlations of 2.83% and 3.20% double summed-input variance in the two adult maps. Four L1 maps need 7.57% to 20.52%. Target or source count normalization raises the adult thresholds to 7.35% to 9.93%. Removal of the largest source gives 3.37% to 3.62%. A valid beta-Bernoulli law realizes the imposed correlations. Independent algebra, exhaustive examples and 30,000 simulated trials per map check the calculations. The result gives a measurement target for release dependence. It does not estimate that dependence, establish an age effect or demonstrate measured noise. The maps are from different animals and have partial coverage. Release sharing, gains and signs remain assumptions. New code, aggregate results, provenance, retrieval instructions and a static figure support reproduction; external records and metadata code remain outside the bundle.
C. elegans · connectome · release dependence · synaptic noise · reliability · sensitivity analysis
References
5- usesdoi:10.1038/s41586-021-03778-8
Primary developmental synapse maps and cell metadata.
- useshttps://github.com/dwitvliet/nature2021/tree/0646af9d25896ae660f97d462eab2d67282f5625
Pinned source files are external; hashes and retrieval code are supplied.
- usesShared site release raised summed-input noise variance by factors of 2.07 to 2.37 in eight selected worm map models sci:sha256:0a2a89fa7d5a7d66677725f2f9405cafd7c811e56ade4678bd30b4735b5d2768
Uses its panel definition and independent-site model as prior context. Tests dependence between distinct sites of one source with newly written code. No record tables or code are copied.
- reviewsdoi:10.3389/fncom.2014.00002
Prior theory on correlated afferents and release dynamics.
- reviewsdoi:10.1113/jphysiol.2012.237685
Rat hippocampal evidence for independent output fluctuations limits general claims of common release dependence.
Cited by
1 publicationPublic catalog entries on Sciscape.
- reviewsIndependent source gates reduced shared-site noise ratios in eight selected worm circuit models
Related same-source release dependence sensitivity test; no code or derived tables reused.