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At gain 0.85 and one leak time, a full FlyWire v783 model with independent 5 micrometre CT1 states had CT1 input norm ratios below 0.473

We tested how local CT1 states change a whole-brain model response. We kept all 139,255 proofread neuron identities and all 54,492,922 chemical contacts in FlyWire 783.0. We replaced the two CT1 states with 6,276 independent spatial cubes of width 5 micrometres. Each target state divided its incoming counts by its full count. All states had equal leak. At coupling gain 0.85 and one leak time, the largest norm ratio found over all CT1 initial patterns was 0.407559. A positive comparison bounded every CT1 input ratio below 0.472432, with the same count magnitudes and any edge signs. Single whole-cell CT1 inputs in the parent model gave ratios 3.129918 and 3.475289. The input budgets differ in their assumed spatial coherence. When every cube had initial amplitude one, the response norm on the 139,253 other neurons stayed within 0.5% of the whole-cell result. An exact one-step identity confirmed preservation of total outgoing influence. Other grids, sign rules and internal coupling tests also gave ratios below one at the tested time. Cubes are assumed states, not measured electrical terminals. This result is a model benchmark, not a measured change in CT1 gain. The package includes the full count graph, selected contact coordinates, code, input patterns, results, figures, source hashes and repeat instructions.

connectome · FlyWire · CT1 · compartment model · transient response · input coherence · whole brain · reproducible benchmark

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References

9
  1. usesAt one leak time and gain 0.85, a full FlyWire count model gave a 3.53-fold norm rise with 96.75% of input on one CT1 neuron sci:sha256:ce3d4d7294b431b2ef984cf8067ed517dac2bbeb3f93900e880bb93d140f0c71

    We use its full graph cache, model rules and CT1 benchmark. We extend its stated compartment limitation with contact-preserving spatial models.

  2. usesdoi:10.5281/zenodo.10676866

    FlyWire connectivity release 783.0 supplies all proofread graph counts and CT1 contact positions.

  3. usesdoi:10.1038/s41586-024-07558-y

    This work describes the FlyWire whole-brain reconstruction and its neuron-node limits.

  4. usesdoi:10.1038/s41586-024-07686-5

    We use the released cell and transmitter labels from annotation version v3.2.0.

  5. supportsdoi:10.1016/j.cub.2019.03.070

    Local CT1 terminal measurements and cable models motivate the compartment sensitivity test.

  6. supportsdoi:10.1038/s41586-024-07939-3

    Its visual-system model already uses separate CT1 column compartments. We add a whole-brain contact-preserving benchmark.

  7. usesdoi:10.1038/s41592-021-01183-7

    The released contact endpoint positions come from this synaptic partner detection work.

  8. usesdoi:10.1016/j.cell.2024.03.016

    The released transmitter predictions come from this work.

  9. doi:10.1371/journal.pcbi.1007655

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