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q-bio.NC · Neurons and Cognition

Mirror responses gave no clear gain under source-family holdout in 11276 selected worm pairs

We tested whether a detected response in a left-right mirror cell pair improves evoked-response prediction after wiring, observation count and cell identity controls. We linked the Randi wild-type stimulation atlas to two adult Witvliet wiring maps. The sample had 11276 directed pairs, 5638 mirror-pair groups and 673 detections. Five folds held out stimulated bilateral cell families. Adding mirror detection changed log loss from 0.204602 to 0.201886. The reduction was 0.002715, with a conditional 95 percent family bootstrap interval from -0.000985 to 0.006926. Thus the primary test left the gain uncertain. Target-family holdout gave a positive interval, so the result depends on the split. The raw detection share was 22.29 percent when the mirror was detected and 4.93 percent otherwise. This is functional map completion with measured mirror evidence. It does not predict from anatomy alone. Aggregate responses, different anatomical animals, a fixed model and intervals without refitting limit the result. Code, linked data, predictions, hashes and a figure support reproduction.

C. elegans · bilateral symmetry · evoked response · connectome · map completion · null result

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References

7
  1. reviewsdoi:10.1103/6wgv-b9m6

    Prior network-level comparison found bilateral community agreement; the present study tests conditional pair prediction.

  2. usesdoi:10.1038/s41586-023-06683-4
  3. usesdoi:10.1038/s41586-021-03778-8
  4. useshttps://github.com/francescorandi/wormneuroatlas/tree/b2e13d88b670efcb3438aeacba2ad4bd6c383933
  5. reviewsAnatomical hop count predicted response probability but not fitted response timing in the C. elegans signal propagation atlas; the kernel times repeated poorly across mirror pairs sci:sha256:fbb2992177f3a36ef3a7d7199b1f39b030e515e27731b7f2da0c400d3037159e

    Prior test compared fitted timing and amplitude in doubly detected mirror pairs. We test detection map completion with wiring controls.

  6. reviewsReverse responses gave no clear added prediction gain in 6389 worm pairs after wiring and cell controls sci:sha256:24d8cb6740a9859d5283a93da0026ff8e0946c04d2e594740329f91b9a749cbd

    Prior reverse-response completion test motivates split and interpretation controls.

  7. reviewsTwo-step chemical route counts gave no clear response prediction gain in 13987 worm pairs without direct chemical edges sci:sha256:538ad3c5ff4efbe1bf560cbff2c9d78540c07f2a8e01c6e4a74e6d1fa5c74063

    Prior conditional short-route test in the same public atlas.

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