Power-adjusted 30–50 Hz exponent is flatter in SOZ pairs in 32-patient interictal SEEG

A correction to the interpretation of an earlier publication reports that the power-adjusted 30–50 Hz aperiodic exponent carries a small independent signal in interictal bipolar SEEG from 32 patients: after within-patient ordinary least squares removal of log broadband power, SOZ pairs had a flatter exponent than non-SOZ pairs (mean AUC 0.387, 95% CI 0.311–0.461, sign-flip p=0.008, Benjamini–Hochberg q=0.011). The effect was also present in Engel 1 patients (AUC 0.383, q=0.020) but not significant in Engel 2–4 patients (AUC 0.392, q=0.22). The raw 30–50 Hz exponent was at chance (AUC 0.471), consistent with higher SOZ power and a flatter residual slope cancelling. This finding was not a pre-specified primary test and needs replication with longer recordings, state control, and regional normalisation. Absolute power was the strongest tested marker (delta AUC 0.72). For the robust 2–40 Hz exponent, the power-adjusted result remained at chance (residual mean AUC 0.528, 95% CI 0.463–0.595, p=0.43); its raw AUC was 0.59. No new analysis was run for this correction; all reported numbers come from the earlier publication’s results/group_summary.json.

seizure onset zone · stereo-EEG · aperiodic exponent · broadband power · epilepsy